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Annex IV: Categories and examples of laboratory uses

(this list is not exhaustive)

1. Research and development (e.g. pharmaceutical, pesticide, CFC and HCFC substitutes)

1.1 Reaction solvent or reaction feedstock (e.g. Diels-Alder and Friedel‑Craft Reactions, RuO3 oxidation, allelic side bromination, etc.)

2. Analytical uses and regulated applications (including quality control)

2.1 Reference

- Chemical (ODS monitoring, volatile organic compound (VOC) Detection, Equipment Calibration)

- Toxicant

- Product (adhesive bond strength, breathing filter test)

2.2 Extraction

- Pesticide and heavy metal detection (e.g. in food)

- Oil mist analysis

- Colour and food additive detection

- Oil detection in water and soil

2.3 Diluent

- Zinc, copper, cadmium detection in plants and food

- Microchemical methods to determine molecular weight or oxygen

- Measuring drug purity and residual determination

- Sterilization of lab equipment

2.4 Carrier (Inert)

- Forensic methods (e.g. fingerprinting)

- Titration (cholesterol in eggs, drug chemical characteristics, "Iodine value", e.g. in oils and chemical products)

- Analytical equipment (Spectroscopy (Infra-red, Ultra-violet, Nuclear Magnetic Resonance, fluorescence), chromatography (High-pressure liquid chromatography, gas chromatography, thin-layer chromatography)


2.5 Tracer


- Sanitary engineering

2.6 Miscellaneous (including testing)

- Ingredient in material for testing (e.g. asphalt, metal fatigue and fracturing)

- Separation media (separation of extraneous materials such as filth and insect excreta from stored food products)

3. Miscellaneous (including biochemical)

3.1 Laboratory method development

3.2 Sample preparation using solvent

3.3 Heat transfer medium